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Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder characterized by abnormal thickening of the heart muscle, which can make it difficult for the heart to pump blood efficiently. HCM is a common cause of sudden cardiac death in young people and athletes.
HCM can be caused by mutations in genes that affect the structure of the heart muscle cells. In many cases, HCM is inherited from a parent who has the condition, although some people may develop the disorder due to a spontaneous mutation.
Symptoms of HCM can vary but may include shortness of breath, chest pain, fainting, dizziness, and palpitations. Some people with HCM may not experience any symptoms.
Diagnosis of HCM typically involves a physical exam, imaging tests such as echocardiography, and genetic testing to identify any genetic mutations that may be causing the condition. Treatment for HCM may include medications to improve heart function, such as beta-blockers or calcium channel blockers, and surgery to remove part of the thickened heart muscle if necessary. In some cases, the implantation of a cardiac defibrillator may be recommended to prevent sudden cardiac death.
If you or someone you know is experiencing symptoms of HCM, it is important to speak with a healthcare provider for an accurate diagnosis and appropriate treatment. With proper management, people with HCM can lead normal, healthy lives, but regular monitoring and treatment are necessary to prevent serious complications.
Hypertrophic cardiomyopathy is usually caused by abnormal genes (gene mutations) that cause the heart muscle to grow abnormally thick.
In most people with hypertrophic cardiomyopathy, the muscular wall (septum) between the two bottom chambers of the heart (ventricles) becomes thicker than normal. As a result, the thicker wall may block blood flow out of the heart. This is called obstructive hypertrophic cardiomyopathy.
If there's no significant blocking of blood flow, the condition is called nonobstructive hypertrophic cardiomyopathy. However, the heart's main pumping chamber (left ventricle) may become stiff. This makes it hard for the heart to relax and reduces the amount of blood the ventricle can hold and send to the body with each heartbeat.
People with hypertrophic cardiomyopathy also have an abnormal arrangement of heart muscle cells (myofiber disarray). This can trigger arrhythmias in some people.
There is no known prevention for hypertrophic cardiomyopathy. But it's important to identify the condition as early as possible to guide treatment and prevent complications.
If you have a first-degree relative — a parent, sibling or child — with hypertrophic cardiomyopathy, doctors may recommend genetic testing to screen for the condition. However, not everyone with HCM has a currently detectable mutation. Also, some insurance companies may not cover genetic testing.
If genetic testing isn't done, or if the results aren't helpful, then your doctor may recommend echocardiograms on a regular basis if you have a family member with hypertrophic cardiomyopathy. Adolescents and competitive athletes should be screened once a year. Adults who don't compete in athletics should be screened every five years.
The goal of hypertrophic cardiomyopathy treatment is to relieve symptoms and prevent sudden cardiac death in people at high risk. Your specific treatment depends on the severity of your symptoms. Together, you and your doctor will discuss the most appropriate treatment for your condition.
Medications can help reduce how strong the heart muscle squeezes and slow the heart rate so that the heart can pump blood better. Medications to treat hypertrophic cardiomyopathy and its symptoms may include:
Several different surgeries or procedures are available to treat cardiomyopathy or its symptoms. They range from open-heart surgery to implantation of a device to control your heart rhythm.