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Common variable immunodeficiency

Common variable immunodeficiency
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Lungs (Respiratory system)


Common variable immunodeficiency
Common variable immunodeficiency

Common variable immunodeficiency (CVID) is a rare, primary immunodeficiency disorder characterized by low levels of immunoglobulins (antibodies) in the blood, leading to recurrent bacterial infections, particularly in the respiratory and gastrointestinal tracts. CVID usually manifests in adulthood, but it can also occur in children. The exact cause of CVID is unknown, but it is believed to involve both genetic and environmental factors. Diagnosis is typically based on blood tests that show low levels of immunoglobulins, as well as an assessment of clinical symptoms. Treatment often involves regular infusions of immunoglobulin replacement therapy to help prevent infections and manage symptoms. Antibiotics, antiviral medications, and other treatments may be used to manage infections as they occur.


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Disease Signs and Symptoms
  • Ear pain
  • Recurrent respiratory infections

Disease Causes

Common variable immunodeficiency

In the vast majority of CVID cases, the cause is unknown. In around 10% of people with CVID, a genetic mutation has been identified. Researchers believe that the condition is caused by a combination of both environmental and genetic factors. As of now, the environmental factors are unclear.


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