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Skin metastases of breast cancer - Generics

Breast cancer is the most common cancer among women worldwide, accounting for 25% of all female cancers. Breast cancer can spread (metastasize) to other parts of the body, including the skin. Skin metastases of breast cancer are a late complication of the disease and occur in approximately 20% of patients with advanced-stage breast cancer.

Skin metastases can take on different forms, such as nodules, papules, plaques, or inflammatory changes. The most common form is a solitary, painless nodule, which may be mistaken for a benign lesion. The skin metastasis may occur near the original site of the tumor or in a distant location. The most common sites of skin metastasis are the chest wall, including the skin overlying the breast, and the abdomen. However, skin metastases can occur anywhere on the body.

The diagnosis of skin metastasis is often made based on clinical examination and a history of breast cancer. However, a skin biopsy may be necessary to confirm the diagnosis. The biopsy may also help to determine the hormone receptor and HER2 status of the metastasis, which can guide treatment decisions.

The treatment of skin metastases of breast cancer depends on several factors, including the extent of disease, the location of the metastasis, and the patient's overall health. Local treatments, such as radiation therapy, cryotherapy, or surgery, may be used to control the skin lesion and relieve symptoms. Systemic treatments, such as chemotherapy, targeted therapy, or hormone therapy, may also be used to treat the underlying breast cancer.

The prognosis of skin metastases of breast cancer is generally poor, with a median survival of approximately 12 months. However, the prognosis can vary depending on several factors, including the extent of disease, the location of the metastasis, and the patient's overall health. Treatment can improve symptoms and quality of life, but it is unlikely to cure the disease.

In conclusion, skin metastases of breast cancer are a late complication of the disease and occur in approximately 20% of patients with advanced-stage breast cancer. The diagnosis is often made based on clinical examination and a history of breast cancer, but a skin biopsy may be necessary to confirm the diagnosis. Treatment depends on several factors and may involve local and/or systemic treatments. The prognosis is generally poor, but treatment can improve symptoms and quality of life.


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