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Primary ovarian failure - Generics

Primary ovarian failure, also known as premature ovarian failure (POF) or premature ovarian insufficiency (POI), is a condition in which the ovaries stop functioning before the age of 40. It is characterized by a decline in the number and function of the ovarian follicles, which are responsible for producing estrogen and releasing eggs.

The exact cause of primary ovarian failure is often unknown, but it can be caused by genetic factors, autoimmune disorders, chemotherapy or radiation therapy, or certain infections.

Symptoms of primary ovarian failure include irregular or absent menstrual periods, hot flashes, night sweats, vaginal dryness, and mood changes. Women with primary ovarian failure may also experience infertility, although some may still be able to conceive with the help of assisted reproductive technologies such as in vitro fertilization.

Treatment for primary ovarian failure involves hormone replacement therapy (HRT) to replace the estrogen and progesterone that the ovaries are no longer producing. This can help alleviate symptoms such as hot flashes and vaginal dryness, and also help protect against the long-term health effects of low estrogen levels, such as osteoporosis.

Other treatments may include fertility treatments such as in vitro fertilization or egg donation, as well as counseling or support groups to help women cope with the emotional and psychological effects of the condition.

It is important for women with primary ovarian failure to receive regular medical care to monitor their hormone levels, bone health, and overall health.


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