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Combipen (3lac unit + 1l...
ACME Laboratories Ltd.
Procaine Penicillin + Benzyl Penicillin - Brands
This is used for the treatment of gonorrhoea, syphilis and other conditions caused by penicillin-sensitive organisms where a long acting compound is required. Procaine Penicillin kills bacteria by interfering in the synthesis of the bacterial cell wall. It is active against most Gram-positive bacteria and a few Gram-negative species, notably Neisseria meningitidis and Neisseria gonnorhoeae. It is active against spirochaetes such as Treponema pallidum.
Pharmacology
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other lactamases.
Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.
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