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Healthcare Pharmaceuticals Ltd.

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Healthcare Pharmaceuticals Ltd.
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Cytara 1000mg / vial

Size: 1000 mg vial Price: 1650.00
IV Infusion IV Infusion
Cytarabine
Cytotoxic Chemotherapy
0.00 (0)





Generic for Diseases

Generic Indications
  • Acute Lymphocytic Leukemia
  • Acute myeloid leukemia
  • Hodgkins lymphoma
  • Leukemia
  • Lymphoma
  • Meningitis

Generic Description

Cytarabine inhibits deoxyribonucleic acid (DNA) synthesis specifically at the S-phase of the cell cycle. It also has an antiviral and immunosuppressant activity.


Component

Drug Indication

Cytarabine is indicated in Leukaemic meningitis, Induction and maintenance of remission in acute leukaemias


Dosage Administration

Intrathecal (Adult)-

  • Leukaemic meningitis: 5-75 mg/m2 or 30-100 mg once every 2-7 days to once daily for 4 or 5 days.
  • For lymphomatous meningitis: 50 mg every 2 wk for 5 doses, then every 4 wk for 5 doses.

Parenteral (Adult)-

Induction and maintenance of remission in acute leukaemias: 

  • As monotherapy: 200 mg/m2 daily by continuous IV infusion for 5 days, at intervals of approx 2 wk.
  • In combination therapy: 100 mg/m2 bid by rapid IV inj or 100 mg/m2 daily by continuous IV infusion both for 7 days. Maintenance: 1-1.5 mg/kg once or twice wkly via IV or SC.

Contraindication

Patient with active meningeal infection.


Side Effect

Nausea, vomiting, fever, rash, diarrhoea, anorexia, oral and anal inflammation or ulceration, hepatic dysfunction, headache, weakness, confusion, thrombocytopenia, fatigue.

Overdose Effects

Symptoms: Irreversible CNS toxicity and death. Severe arachnoiditis including encephalopathy.

Management: Therapy cessation followed by treatment of ensuing bone marrow depression including whole blood or platelet transfusion and antibiotics. Maintain vital functions.


Precaution Warning

Patient with previous drug-induced bone marrow suppression. Renal or hepatic impairment. Pregnancy and lactation.

Pregnancy & Lactation

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).





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