Tufnil is a preparation of tolfenamic acid. It is an NSAID with anti-inflammatory, analgesic and antipyretic effects. Tolfenamic acid acts by inhibiting prostaglandin and leukotriene synthesis.

Tolfenamic acid is used specifically for relieving the pain of migraine headache and also recommended for use as an analgesic in post-operative pain and fever.

Adult:

• Acute migraine attacks: 200 mg when symptoms appear may be repeated once after 1-2 hour.
• Mild to moderate pain: 100-200 mg tid
• Renal impairment: Dose adjustments may be needed.
• Severe renal impairment: Avoid.

Children: A pediatric dosage regimen has not yet been established.

Tolfenamic acid should be taken with food. Take water during or immediately after meals.

Active peptic ulcer or bleeding in the gut. Severe heart, kidney or liver failure.

Dysuria especially in males, diarrhoea, nausea epigastric pain, vomiting, dyspepsia, erythema, headache, tremor, euphoria, fatigue, pulmonary infiltration & haematuria. Potentially fatal: Blood dyscrasias and hepatitis.

Overdose Effects

Symptoms include headache, nausea, vomiting, epigastric pain. gastrointestinal bleeding, diarrhoea excitation, coma, drowsiness dizziness, tinnitus, fainting and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Patients should be treated symptomatically as required.

Precaution should be needed for patients with asthma bronchospasm, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, cardiac or renal function impairment and elderly. Increase water intake or dose reduction to reduce dysuria.

Pregnancy & Lactation

This medicine is not recommended for using during pregnancy unless considered essential by doctor Not to be given during the third trimester of pregnancy. NSAID's can appear in breast milk in very low concentrations NSAID's should, if possible, be avoided when breastfeeding.