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Tenofovir Alafenamide Brands
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Alenvir 25mg
Square Pharmaceuticals Ltd.
Tablet Tablet
Size: 10 | Price: 900.00
Alfavir 25mg
Incepta Pharmaceuticals Ltd.
Tablet Tablet
Size: 10 | Price: 900.00
Tranbit 25mg
Genvio Pharma Ltd.
Tablet Tablet
Size: 30 | Price: 2700.00
Nexataf 25mg
Everest Pharmaceuticals Ltd.
Tablet Tablet
Size: 30 | Price: 2700.00

Tenofovir Alafenamide - Brands

Tenofovir alafenamide is a phosphonamidate prodrug of tenofovir (2'-deoxyadenosine monophosphate analog). Tenofovir alafenamide as a lipophilic cell-permeant compound enters primary hepatocytes by passive diffusion and by the hepatic uptake transporters OATP1B1 and OATP1B3. Tenofovir alafenamide is then converted to tenofovir through hydrolysis primarily by carboxylesterase 1 (CES1) in primary hepatocytes. Intracellular tenofovir is subsequently phosphorylated by cellular kinases to the pharmacologically active metabolite tenofovir diphosphate. Tenofovir diphosphate inhibits HBV replication through incorporation into viral DNA by the HBV reverse transcriptase, which results in DNA chain-termination.

Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases that include mitochondrial DNA polymerase γ and there is no evidence of toxicity to mitochondria in cell culture.


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