welcome Welcome

“May all be happy, may all be healed, may all be at peace and may no one ever suffer."


Loading...

Ponatinib Hydrochloride

15mg
Tyrosine Kinase Inhibitor
0.00 (0)


Action Period: ...

Ponatinib is a kinase inhibitor. Ponatinib inhibited the in vitro tyrosine kinase activity of ABL and T315I mutant ABL with IC 50 concentrations of 0.4 nM and 2.0 nM, respectively. Ponatinib inhibited the in vitro activity of additional kinases with IC 50 concentrations between 0.1 nM and 20 nM, including members of the VEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and KIT, RET, TIE2, and FLT3. Ponatinib inhibited the in vitro viability of cells expressing native or mutant BCR-ABL, including T315I. In mice, treatment with ponatinib reduced the size of tumors expressing native or T315I mutant BCR-ABL when compared to controls.


Generic for Diseases

Generic Indications

Complement Generics
Similar Generics
Inimical Generics

Component

Drug Indications

Ponatinib is a kinase inhibitor indicated for the:

  • Treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) or Ph+ ALL for whom no other tyrosine kinase inhibitor (TKI) therapy is indicated.
  • Treatment of adult patients with T315I-positive CML (chronic phase, accelerated phase, or blast phase) or T315I-positive Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL).

Dosage Administration

Recommended dose: 45 mg taken orally once daily with or without food

Hepatic Impairment: 30 mg orally once daily. Modify or interrupt dosing for hematologic and non-hematologic toxicity


Contraindication

None


Side Effect

The most common non-hematologic adverse reactions (≥20%) were, abdominal pain, rash, constipation, headache, dry skin, arterial occlusion, fatigue, hypertension, pyrexia, arthralgia, nausea, diarrhea, lipase increased, vomiting, myalgia and pain in extremity.


Precaution Warning

Use in Special Populations

Pediatric Use: Safety and effectiveness have not been established in pediatric patients.

Pregnancy & Lactation

Based on its mechanism of action and findings in animals, Ponatinib can cause fetal harm when administered to a pregnant woman. There are no available data on Ponatinib use in pregnant women. In animal reproduction studies, oral administration of ponatinib to pregnant rats during organogenesis caused adverse developmental effects at doses lower than human exposures at the recommended human dose. Advise pregnant women of the potential risk to a fetus.

There is no data on the presence of ponatinib in human milk, the effects on the breastfed infant or on milk production.





Store

Ponatinib Hydrochloride

There is a list and complete profile of all allopathic generics available in the country where users can make various comments and give ratings. Generic similar to a generic, antagonistic generic, generic instructions, dosage administration, directions, side effects, warnings, ingredients, etc. have been added.

...
Vildagliptin
Endocrine & metabolic system drugs
...
Benzyl Penicillin
Antimicrobial drugs
...
Doxepin (Topical)
Dermatological Preparations
...
Pregabalin
Central Nervous System Drugs
...
Lyophilized Bacterial Lysate
Antimicrobial drugs
...
Conjugated Estrogen (Tablet)
Endocrine & Metabolic System Drugs
...
Vancomycin Hydrochloride
Antimicrobial drugs
...
Amikacin
Antimicrobial Drugs

Searching Keywords Idea
...

Bangladesh is Number One in Digital Medical Management.
To be happy, beautiful, healthy, wealthy, hale and long-lived stay with DM3S.