Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.

Diloxanide is indicated for intestinal amoebiasis

Adult: The recommended dose is 500 mg 3 times/day for 10 days. May repeat course if needed.

Child: >25 kg: 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.

Hypersensitivity.

The frequency of these side-effects is unknown flatulence, itching, urticaria, vomiting

Caution should be exercised in pregnant and breastfeeding women. Avoid excess dosage.

Pregnancy & Lactation

Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.