Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of clotrimazole is against dividing and growing organisms. Clotrimazole inhibits ergosterol synthesis, resulting in abnormal cellular permeability. This inhibits fungal growth. It has also antibacterial activity.

Pharmacology

Clotrimazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells.

Clotrimazole Ear Drop is indicated for the treatment of fungal infections of the ear.

Instill 2-3 drops of Clotrimazole Ear Drops in the affected ear two or three times daily. The treatment should be continued for at least two weeks after the disappearance of all signs of infection to prevent re-infection.

Individuals who have hypersensitivity to any of its components.

Clotrimazole is generally well tolerated after local application but the few side effects have been reported infrequently like erythema, stinging, edema, pruritus and general irritation.

Overdose Effects

In case of accidental oral ingestion, supportive measures should be taken.