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Bupivacaine Hydrochloride Brands
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Ultracaine 0.50%
Jayson Pharmaceuticals Ltd.
Injection Injection
Size: 30 ml vial | Price: 60.42
Ultracaine 0.25%
Jayson Pharmaceuticals Ltd.
Injection Injection
Size: 20 ml vial | Price: 35.53
Nerkein 0.50%
Beximco Pharmaceuticals Ltd.
Injection Injection
Size: 30 ml vial | Price: 60.00
Bupi 0.50%
Popular Pharmaceuticals Ltd.
Injection Injection
Size: 30 ml vial | Price: 60.23

Bupivacaine Hydrochloride - Brands

Bupivacaine injectioin is a preparation of bupivacaine, a long acting local anaesthetic agent that belongs to amide group. It blocks the generation and the conduction of nerve impulses, by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential.

Bupivacaine binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. Without depolarization, no initiation or conduction of a pain signal can occur.

The rate of systemic absorption of bupivacaine and other local anesthetics is dependent upon the dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the preparation.

  • Onset of action (route and dose-dependent): 1-17 min
  • Duration of action (route and dose-dependent): 2-9 hr
  • Half life: neonates, 8.1 hr, adults: 2.7 hr
  • Time to peak plasma concentration (for peripheral, epidural, or caudal block): 30-45 min
  • Protein binding: about 95%
  • Metabolism: hepatic
  • Excretion: renal (6% unchanged)

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