Aripiprazole is an atypical antipsychotic that has both dopamine and serotonin receptors activity. It is a partial agonist of dopamine D2 receptors that relieves the symptoms of schizophrenia. It is characterized as a dopamine system stabilizer. It is a potent partial agonist at serotonin 5-HT1A receptors and antagonist at 5-HT2A receptors. This is associated with improvement of depressive, cognitive and negative symptoms.

Aripiprazole is indicated for-

• Schizophrenia
• Schizoaffective disorder
• Acute manic and mixed episodes associated with Bipolar I Disorder
• Maintaining efficacy in patients with Bipolar I Disorder who are stabilized

For Schizophrenia: 10 to 15 mg, once daily, without regard to food. Dose increment should not be made before 2 weeks, the time needed to achieve steady state.

For Bipolar mania: 30 mg, once daily, without regard to food.

Aripiprazole is contraindicated in patients who are hypersensitive to it or to any component of this product.

Headache, constipation, asthenia, nausea, dyspepsia, vomiting, coughing, abdominal pain.

Pregnancy & Lactation

Aripiprazole should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking aripiprazole.

Precautions & Warnings

Aripiprazole may be associated with orthostatic hypotension (orthostatic lightheadedness).

Aripiprazole should be used with caution in patients with known cardiovascular disease (myocardial infarction or ischaemic heart disease, heart failure or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications).

Seizures occurred in aripiprazole-treated patients. As with other antipsychotic drugs, aripiprazole should be used cautiously in patients with Alzheimer's dementia.

Aripiprazole is not approved for the treatment of patients with dementia-related psychosis.