Each vial contains:

• Vitamin B 1 (as Thiamine Nitrate): 2.5 mg
• Vitamin B 2 (as Riboflavin Sodium Phosphate): 3.6 mg
• Nicotinamide: 40 mg
• Vitamin B 6 (as Pyridoxine Hydrochloride): 4 mg
• Pantothenic Acid (as Dexpanthenol): 15 mg
• Ascorbic Acid (as Sodium Ascorbate): 100 mg
• Biotin: 0.06 mg
• Folic Acid: 0.4 mg
• Vitamin B 12 (as Cyanocobalamin): 0.005 mg

This IV preparation is intended as a supplement for intravenous nutrition in order to meet the daily requirements of the water-soluble vitamins in infants, children and adults.

Adults and children weighing 10 kg or more: 1 vial (10 ml) daily.

Children weighing less than 10 kg: should be given 1 ml of the dissolved mixture per kg body weight/day.

Administration

The contents of one vial are dissolved by the aseptic addition of 10 ml of one of the following:

• Water for injection
• Fat emulsion 10%
• Glucose solution for infusion (5% to 60%)
• Normal saline (0.9% Sodium Chloride)

This IV preparation may be added to parenteral nutrition admixtures containing carbohydrates, lipids, amino acids, electrolytes, and trace elements provided that compatibility and stability have been confirmed.

Known hypersensitivity to any of the components, e.g. Thiamine.

Allergic reactions may occur in patients hypersensitive to any component of the preparation, e.g. Thiamine.

Overdose Effects

No adverse effects of an overdose of water soluble multivitamin have been reported, with exception of cases of extremely high parenteral doses. The possibility of hypervitaminosis A and D should be considered if the content of This IV preparation is dissolved in another multivitamin injection.

This IV preparation is diluted with water-based solutions, the admixture should be protected from light. This is not necessary if this IV preparation is diluted with intralipid because of the protective effect of the fat emulsion.

Pregnancy & Lactation

Animal reproduction studies or clinical investigations during pregnancy have not been carried out with this preparation. However, there are published reports on safe administration of water soluble vitamins in this patient group.